Crosslinked pH-responsive polymersome via Diels-Alder click chemistry: A reversible pH-dependent vesicular nanosystem

Controlling pH Responsive Polymersome Assembly

Vesicles are formed when a membrane curves to produce a spherical structure, which in turn entraps an aqueous volume within its lumen. When these structures are formed using a polymers, a polymeric vesicle or “Polymersome” is formed. The biomimetic nature of these assemblies has attracted much attention in the field of biomedicine over the last decade, especially with regards to therapeutic or ...

A new class of dual responsive self-healable hydrogels based on a core crosslinked ionic block copolymer micelle prepared via RAFT polymerization and Diels-Alder "click" chemistry.

Amphiphilic diblock copolymers of poly(furfuryl methacrylate) (PFMA) with cationic poly(2-(methacryloyloxy)ethyltrimethyl ammonium chloride) (PFMA-b-PMTAC) and anionic poly(sodium 4-vinylbenzenesulfonate) (PFMA-b-PSS) were prepared via reversible addition fragmentation chain-transfer (RAFT) polymerization by using PFMA as a macro-RAFT agent. The formation of the block copolymer was confirmed by...

A pH-responsive, low crosslinked, molecularly imprinted insulin delivery system

A new type of insulin delivery system capable of better self-regulating the release of insulin was reported in this study. This insulin delivery system was made of a low crosslinked insulin-imprinted hydrogel that exhibited pH-dependent interpolymer interactions between poly(methacrylic acid) (PMAA) and poly(ethylene glycol) (PEG). At acidic conditions (such as pH 3.5), this delivery system res...

pH responsive polymersome Pickering emulsion for simple and efficient Janus polymersome fabrication.

Crosslinked poly(acrylic acid)-b-polystyrene polymersomes were successfully employed to form a water-in-oil Pickering emulsion and enabled an easy and reversible disassembly due to the pH sensitivity. The side of the polymersomes exposed to the water phase was selectively modified with metal nanoparticles, allowing facile formation of anisotropically modified Janus polymersomes.

Immuno-polymeric nanoparticles by Diels-Alder chemistry.